E2F1 Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA5142947 | 100 µg | 415,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Additional Information: Reported isoforms represent identical protein: NP_524437.2; NP_732646.1; NP_732647.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC |
Regulatory Status | RUO |
Immunogen | Peptide with sequence C-TKGLFQTPYRSARN. |
Host | Gt |
Genebank | E2F1 |
Isotype | IgG |
Crossreactivity | Drosophila |
Clonality | Pab |
Format | Liquid; TBS; pH 7.3, with 0.5% BSA and 0.02% sodium azide |
Concentration | 0.5 mg/mL |
Working Dilution | Immunocytochemistry (Assay-dependent), Immunohistochemistry (0.5 µg/mL) |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: PA5-142947 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |