N-cadherin Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA517526 | 100 µL | 594,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
It is not recommended to aliquot this antibody. N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
Category | Antibody |
Supplier | ThermoFisher |
Application | IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Two synthetic peptides corresponding to two conserved regions of human N-Cadherin |
Host | Rb |
Genebank | CDH2 |
Isotype | IgG |
Crossreactivity | Bo, Drosophila, Hu, Ms, Primate, Rt, Zebrafish |
Clonality | Pab |
Format | Liquid; 0.01M HEPES; pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol and no preservative |
Concentration | 9 µg/mL |
Working Dilution | Western Blot (1:1,000), Immunoprecipitation (1:25), Immunohistochemistry (Paraffin) (1:100) |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20°C |
Disclaimer | Alternative CatNo: PA5-17526 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |