ITCH Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA518662 | 100 µg | 678,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody is predicted to react with canine, mouse and rat based on sequence homology. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | FC, ICC, IP, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Synthetic peptide sequence (EIKSHDLKPNGGN) corresponding to the internal amino acids of ITCH |
| Host | Gt |
| Genebank | ITCH |
| Isotype | IgG |
| Crossreactivity | Hu |
| Clonality | Pab |
| Format | Liquid; TBS; pH 7.3, with 0.5% BSA and 0.02% sodium azide |
| Concentration | 0.5 mg/mL |
| Working Dilution | Western Blot (0.1-0.3 µg/mL), Immunocytochemistry (Assay-dependent), Flow Cytometry (Assay-depend... |
| Purity | Antigen affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: PA5-18662 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Wet Ice |
| Material Safety Data Sheet | Download PDF |
