OCT4 Polyclonal Antibody, DyLight™ 550
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA522736 | 100 µL | 656,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The target sequence has 93% sequence homology with bovine and porcine. POU5F1, also commonly known as Oct-4, is a maternally expressed octamer-binding protein that was the first transcription factor described for the early stages of development. The role of POU5F1 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing POU5F1, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | FC, ICC, IHC, WB |
| Regulatory Status | RUO |
| Immunogen | A synthetic peptide made to an internal portion of the human OCT4 protein sequence (between residues 100-200). |
| Host | Rb |
| Genebank | POU5F1 |
| Isotype | IgG |
| Crossreactivity | Bo, Hu, Ms, Primate, Rt |
| Clonality | Pab |
| Format | Liquid; 50mM sodium borate; , with 0.05% sodium azide |
| Concentration | 0.69 mg/mL |
| Working Dilution | Immunocytochemistry (Assay-Dependent), Flow Cytometry (Assay-Dependent), Immunohistochemistry (As... |
| Purity | Antigen affinity chromatography |
| Conjugation | DY 550 |
| Storage Conditions | 4° C, store in dark |
| Disclaimer | Alternative CatNo: PA5-22736 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
