53BP1 Polyclonal Antibody, DyLight™ 488
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA522759 | 100 µL | 656,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Human samples have been tested in Western Blot and ICC/IF, and mouse samples have been tested in ICC/IF only. Suggested positive control: U205, 293T, and MO59K cell lysates and MEF lysates . 53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | FC, ICC, IHC, WB |
| Regulatory Status | RUO |
| Immunogen | The epitope recognized by this antibody maps to a region between residues 1925 and the C-terminus (residue 1972) of human tumor protein p53 binding protein 1 using the numbering given in entry NP_0... |
| Host | Rb |
| Genebank | TP53BP1 |
| Isotype | IgG |
| Crossreactivity | Bat, Bo, Dg, Hu, Ms, Rt, Rodent |
| Clonality | Pab |
| Format | Liquid; 50mM sodium borate; , with 0.05% sodium azide |
| Concentration | 0.5 mg/mL |
| Working Dilution | Immunohistochemistry (Frozen) (Assay-Dependent), Flow Cytometry (Assay-Dependent), Immunohistoche... |
| Purity | Antigen affinity chromatography |
| Conjugation | DY 488 |
| Storage Conditions | 4° C, store in dark |
| Disclaimer | Alternative CatNo: PA5-22759 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
