53BP1 Polyclonal Antibody, DyLight™ 550
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA522794 | 100 µL | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody reacts with Human samples in Western blot and ICC applications, and with Mouse in ICC applications. 53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | A synthetic peptide, which represented a portion of human tumor protein p53-binding protein 1 encoded in exon 11, 12 and 19 (LocusLink ID 7158). This antibody is a cocktail hybrid of NB 100-304 and... |
Host | Rb |
Genebank | TP53BP1 |
Isotype | IgG |
Crossreactivity | Hu, Ms |
Clonality | Pab |
Format | Liquid; 50mM sodium borate; , with 0.05% sodium azide |
Concentration | 0.61 mg/mL |
Working Dilution | Flow Cytometry (2-5 µg/mL), Immunohistochemistry (Paraffin) (Assay-Dependent), Immunocytochemistr... |
Purity | Antigen affinity chromatography |
Conjugation | DY 550 |
Storage Conditions | 4° C, store in dark |
Disclaimer | Alternative CatNo: PA5-22794 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |