DISC1 Polyclonal Antibody, DyLight™ 550
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA522840 | 100 µL | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The theoretical molecular weight of DISC1 is ~90 kDa. Due to alternative splicing, DISC1 may also run at ~75 and 100 kDa. Suggested positive control: human brain sections (neurons and glia). DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein that interacts with multiple proteins of the centrosome and cytoskeletal system, and is involved in neuronal functions that are dependent upon proper cytoskeletal regulation, including neuronal migration, neurite architecture and intracellular transport. Regions of the brain which express DISC1 include the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum and paraventricular hypothalamus, and loss of DISC1 function results in differences in structural organization.The DISC1 gene locus is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2, beta 4-spectrin; and proteins which tr
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC |
Regulatory Status | RUO |
Immunogen | A synthetic peptide made to an internal region (within residues 400-500) of the rat DISC1 protein. |
Host | Rb |
Genebank | DISC1 |
Isotype | IgG |
Crossreactivity | Hu, Ms, Rt |
Clonality | Pab |
Format | Liquid; 50mM sodium borate; , with no preservative |
Concentration | 0.85 mg/mL |
Working Dilution | Immunohistochemistry (Frozen) (2.5-5.0 µg/mL), Immunohistochemistry (Paraffin) (2.5-5 µg/mL), Imm... |
Purity | Antigen affinity chromatography |
Conjugation | DY 550 |
Storage Conditions | 4° C, store in dark |
Disclaimer | Alternative CatNo: PA5-22840 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |