ABCA1 Polyclonal Antibody, DyLight™ 550
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA522910 | 100 µL | 652,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | EL, FC, ICC, IHC, WB |
| Regulatory Status | RUO |
| Immunogen | Partial peptide sequence (peptide used resides somewhere between a.a 1100-1300) of the human ABCA1 gene. Actual immunogen sequence is proprietary information. |
| Host | Rb |
| Genebank | ABCA1 |
| Isotype | IgG |
| Crossreactivity | Dg, Ck, Ho, Hm, Hu, Ms, Mustelid, Primate, Pg, Rb, Rt |
| Clonality | Pab |
| Format | Liquid; 50mM sodium borate; , with 0.05% sodium azide |
| Concentration | 0.75 mg/mL |
| Working Dilution | Immunohistochemistry (Frozen) (Assay-Dependent), Flow Cytometry (1:10-1:1,000), Immunocytochemist... |
| Purity | Antigen affinity chromatography |
| Conjugation | DY 550 |
| Storage Conditions | 4° C, store in dark |
| Disclaimer | Alternative CatNo: PA5-22910 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
