CCR2 Polyclonal Antibody, HRP
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA523041 | 100 µL | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | IHC, WB |
| Regulatory Status | RUO |
| Immunogen | Synthetic peptide made to an N-terminal portion of the human CCR2 protein (within residues 20-100). |
| Host | Rb |
| Genebank | CCR2 |
| Isotype | IgG |
| Crossreactivity | Bo, Ca, Hu, Rt |
| Clonality | Pab |
| Format | Liquid; PBS; , with no preservative |
| Concentration | 1 mg/mL |
| Working Dilution | Immunohistochemistry (Paraffin) (Assay-Dependent), Western Blot (1 µg/mL) |
| Purity | Antigen affinity chromatography |
| Conjugation | HRP |
| Storage Conditions | 4° C, store in dark |
| Disclaimer | Alternative CatNo: PA5-23041 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
