STRAP Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA523165 | 100 µg | 674,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | IHC, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Synthetic peptide (241 GGEDFKLYKYDYNSGEELES 260) of Serine/Threonine Kinase Receptor Associated Protein protein. |
| Host | Rb |
| Genebank | STRAP |
| Isotype | IgG |
| Crossreactivity | Bo, Dg, Ho, Hu, Ms, Primate |
| Clonality | Pab |
| Format | Liquid; PBS; , with 0.2% gelatin and 0.05% sodium azide |
| Concentration | 0.5 mg/mL |
| Working Dilution | Immunohistochemistry (Paraffin) (10 µg/mL), Western Blot (1-2 µg/mL) |
| Purity | Protein G |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: PA5-23165 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Wet Ice |
| Material Safety Data Sheet | Download PDF |
