PACS1 Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA523291 | 100 µg | 734,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
PACS-1 (CRA_a) is a 963 amino acid rich regulatory protein involved in protein trafficking and belongs to the PACS family. A coat protein involved in controlling the correct subcellular localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs, PACS-1 is also known to be involved in HIV-1 Nef-mediated removal of MHC-I from the cell surface to the TGN, thus enabling HIV-1 to escape immune surveillance. PACS-1 also controls the endosome to Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin coated membrane pits. Usually seen in golgi apparatus, trans-Golgi network and localized in the paranuclear region, it is ubiquitously expressed in most of the tissues.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Synthetic peptide (304 EDEDLRKVKKTRRK 317) of PACS-1 protein. |
| Host | Rb |
| Genebank | PACS1 |
| Isotype | IgG |
| Crossreactivity | Bo, Dg, Ho, Hu, Marsupial, Ms, Primate |
| Clonality | Pab |
| Format | Liquid; PBS; , with 0.05% BSA and 0.05% sodium azide |
| Concentration | 0.5 mg/mL |
| Working Dilution | Western Blot (0.05-0.1 µg/mL) |
| Purity | Antigen affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: PA5-23291 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
