beta-Arrestin 2 Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA523296 | 100 µg | 678,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | IHC, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Synthetic peptide (LGKRDFVDHLDKVDPVDG (aa23-40)) of ARRB2 protein. |
| Host | Rb |
| Genebank | ARRB2 |
| Isotype | IgG |
| Crossreactivity | Bo, Dg, Ck, Ho, Hu, Ms, Primate, Rt, Xenopus, Zebrafish |
| Clonality | Pab |
| Format | Liquid; PBS; , with 0.05% sodium azide |
| Concentration | 0.5 mg/mL |
| Working Dilution | Immunohistochemistry (Paraffin) (5 µg/mL), Western Blot (0.25-0.1 µg/mL) |
| Purity | Antigen affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: PA5-23296 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
