KCNMA1 Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA533871 | 50 µg | 590,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
Category | Antibody |
Supplier | ThermoFisher |
Application | IHC |
Regulatory Status | RUO |
Immunogen | Synthetic 15 amino acid peptide from internal region of human KCNMA1. |
Host | Rb |
Genebank | KCNMA1 |
Isotype | IgG |
Crossreactivity | Bo, Dg, Ck, Hm, Hu, Monkey, Ms, Pg, Rb, Rt, Xenopus |
Clonality | Pab |
Format | Liquid; PBS; , with 0.1% sodium azide |
Concentration | 0.8 mg/mL |
Working Dilution | Immunohistochemistry (Paraffin) (2.5 µg/mL) |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C |
Disclaimer | Alternative CatNo: PA5-33871 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |