EAR2 Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA534008 | 50 µg | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
Category | Antibody |
Supplier | ThermoFisher |
Application | IHC |
Regulatory Status | RUO |
Immunogen | Synthetic 16 amino acid peptide from ligand-binding domain of human NR2F6. |
Host | Rb |
Genebank | NR2F6 |
Isotype | IgG |
Crossreactivity | Bo, Dg, Hm, Hu, Monkey, Ms, Rt, Xenopus, Zebrafish |
Clonality | Pab |
Format | Liquid; PBS; , with 0.1% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunohistochemistry (Paraffin) (5 µg/mL) |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C |
Disclaimer | Alternative CatNo: PA5-34008 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |