SCN1A Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA534187 | 50 µg | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
BLAST analysis of the peptide immunogen showed 100% homology with human protein SCN2A and 94% homology with SCN3A. Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddels syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
Category | Antibody |
Supplier | ThermoFisher |
Application | IHC |
Regulatory Status | RUO |
Immunogen | Synthetic 16 amino acid peptide from N-terminus of human SCN1A / Nav1.1. |
Host | Rb |
Genebank | SCN1A |
Isotype | IgG |
Crossreactivity | Bat, Dg, Ck, Ho, Hm, Hu, Monkey, Ms, Pg, Rt, Xenopus |
Clonality | Pab |
Format | Liquid; PBS; , with 0.1% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunohistochemistry (Paraffin) (5 µg/mL) |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C |
Disclaimer | Alternative CatNo: PA5-34187 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |