TRPM8 Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA534286 | 50 µg | 678,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. TRPM8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. TRPM8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | IHC |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Synthetic 15 amino acid peptide from internal region of human TRPM8. |
| Host | Rb |
| Genebank | TRPM8 |
| Isotype | IgG |
| Crossreactivity | Dg, Ck, Ho, Gp, Hm, Hu, Rb, Rt |
| Clonality | Pab |
| Format | Liquid; PBS; , with 0.1% sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | Immunohistochemistry (Paraffin) (2.4 µg/mL) |
| Purity | Antigen affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: PA5-34286 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
