3-Methylcytosine Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA540098 | 50 µg | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
3-methylcytosine arises by erroneous methylation of DNA through spontaneous exposure to endogenous S-adenosyl methionine (SAM). Since the N3-position in cytosine is protected in double stranded DNA, this phenomenon mainly occurs in single stranded DNA. The resulting 3-mC is toxic and mutagenic and increased levels of 3-mC seem to impair cell proliferation. Therefore, it has to be repaired by the cell. This is established by oxidative demethylation, which is catalyzed by the AlkB protein.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | Parray |
| Regulatory Status | RUO |
| Immunogen | Human BSA-conjugated 3-methylcytosine (3-mC). |
| Host | Rb |
| Isotype | IgG |
| Crossreactivity | Hu, Ms |
| Clonality | Pab |
| Format | Liquid; PBS; pH 7.4, with 0.05% ProClin 300, 0.05% sodium azide |
| Concentration | 1.8 mg/mL |
| Working Dilution | Peptide array (1:400) |
| Purity | Protein G |
| Conjugation | Unconjugated |
| Storage Conditions | -20°C or -80°C if preferred |
| Disclaimer | Alternative CatNo: PA5-40098 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
