TWIST1 Polyclonal Antibody, FITC
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA546889 | 100 Tests | 436,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
In direct ELISAs, less than 16% cross-reactivity with recombinant human Twist-2 is observed. TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | FC |
| Regulatory Status | RUO |
| Immunogen | E. coli-derived recombinant human Twist-1 Met1-His202 |
| Host | Sh |
| Genebank | TWIST1 |
| Isotype | IgG |
| Crossreactivity | Hu |
| Clonality | Pab |
| Format | Liquid; Buffered saline solution; , with BSA and 0.09% sodium azide |
| Working Dilution | Flow Cytometry (10 µL per million cells) |
| Purity | Antigen affinity chromatography |
| Conjugation | FITC |
| Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
| Disclaimer | Alternative CatNo: PA5-46889 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
