CD127 Polyclonal Antibody, PE
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA546900 | 100 Tests | 618,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
In direct ELISAs, approximately 60% cross-reactivity with recombinant mouse IL-7 R alpha and less than 10% cross-reactivity with recombinant human IL-7 R alpha is observed. CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. CD127 consists of an alpha chain and a gamma chain. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. The biological effects of IL7 are mediated by the binding of IL7 to the specific cell surface receptor. Diseases associated with CD127 dysfunction include severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | Mouse myeloma cell line NS0-derived recombinant rat IL-7 R alpha/CD127 Glu21-Asp239 |
Host | Sh |
Genebank | IL7R |
Isotype | IgG |
Crossreactivity | Rt |
Clonality | Pab |
Format | Liquid; Buffered saline solution; , with BSA and 0.09% sodium azide |
Working Dilution | Flow Cytometry (10 µL per million cells) |
Purity | Antigen affinity chromatography |
Conjugation | PE |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: PA5-46900 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |