TSLP Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA546975 | 100 µg | 676,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
In sandwich ELISAs, less than 0.1% cross-reactivity with recombinant mouse TSLP and recombinant human TSLP R is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method. TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, N, WB |
Regulatory Status | RUO |
Immunogen | E. coli-derived recombinant human TSLP Tyr29-Gln159 |
Host | Sh |
Genebank | TSLP |
Isotype | IgG |
Crossreactivity | Hu |
Clonality | Pab |
Format | Lyophilized; PBS; , with 5% trehalose and No Preservative |
Concentration | 0.2 mg/mL |
Working Dilution | ELISA (0.1-0.4 µg/mL (Detection), 0.2-0.8 µg/mL (Capture)), Neutralization (0.05-0.25 µg/mL), Wes... |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: PA5-46975 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |