SCF Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA547284 | 100 µg | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
In Western blots, approximately 60% cross-reactivity with recombinant mouse SCF is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, WB |
Regulatory Status | RUO |
Immunogen | E. coli-derived recombinant feline SCF/c-kit Ligand Lys26-Ala190 |
Host | Gt |
Genebank | KITLG |
Isotype | IgG |
Crossreactivity | Ca |
Clonality | Pab |
Format | Lyophilized; PBS; , with 5% trehalose and No Preservative |
Concentration | 0.2 mg/mL |
Working Dilution | Immunocytochemistry (10-20 µg/mL), Western Blot (0.1 µg/mL) |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: PA5-47284 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |