GLI2 Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA547500 | 100 µg | 608,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
In direct ELISAs and Western blots, approximately 25% cross-reactivity with recombinant mouse GLI-2 and 5% cross-reactivity with recombinant human (rh) GLI-1 and rhGLI-3 is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Gli-2 belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ChIP, IHC, WB |
| Regulatory Status | RUO |
| Immunogen | E. coli-derived recombinant human GLI-2 Ala2-Glu91 |
| Host | Sh |
| Genebank | GLI2 |
| Isotype | IgG |
| Crossreactivity | Hu |
| Clonality | Pab |
| Format | Lyophilized; PBS; , with 5% trehalose and No Preservative |
| Concentration | 0.2 mg/mL |
| Working Dilution | Immunohistochemistry (5-15 µg/mL), ChIP Assay (5 µg/5 x 10^6 cells), Western Blot (0.1 µg/mL) |
| Purity | Antigen affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
| Disclaimer | Alternative CatNo: PA5-47500 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
