IL-1 beta Polyclonal Antibody

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Product Description

In direct ELISAs, approximately 40% cross-reactivity with recombinant feline IL-1 beta is observed, less than 10% cross-reactivity with recombinant human IL-1 beta, recombinant rhesus macaque IL-1 beta, recombinant equine IL-1 beta, and recombinant porcine IL-1 beta is observed, less than 5% cross-reactivity with recombinant mouse (rm) IL-1 beta, recombinant rat IL-1 beta, and recombinant cotton rat (rcr) IL-1 beta is observed, and less than 1% cross-reactivity with rcrIL-1 alpha, rmIL-1ra, and recombinant canine IL-18 is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method. Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for class