c-Met Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA547585 | 100 µg | 580,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
In sandwich ELISAs, less than 0.2% cross-reactivity with recombinant human HGF R and remombinant mouse HGF R is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method. MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, N, WB |
Regulatory Status | RUO |
Immunogen | Mouse myeloma cell line NS0-derived recombinant canine HGF R/c-MET Glu25-Leu935 |
Host | Gt |
Genebank | MET |
Isotype | IgG |
Crossreactivity | Dg |
Clonality | Pab |
Format | Lyophilized; PBS; , with 5% trehalose and No Preservative |
Concentration | 0.2 mg/mL |
Working Dilution | ELISA (0.1-0.4 µg/mL (Detection), 0.2-0.8 µg/mL (Capture)), Western Blot (0.1 µg/mL), Neutralizat... |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: PA5-47585 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |