DARC Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA547861 | 100 µg | 738,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL. ACKR1 or DARC is an atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades resulting instead in chemokine sequestration, degradation, or transcytosis. ACKR1 is also known as an interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. It has a promiscuous chemokine-binding profile by interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. ACKR1 also acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and for the malaria parasites P.vivax and P.knowlesi.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | FC, IHC, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | E. coli-derived recombinant mouse DARC Met1-Pro61, Ala115-Cys127, Ser186-Lys205, Tyr264-Asn285 |
| Host | Sh |
| Genebank | ACKR1 |
| Isotype | IgG |
| Crossreactivity | Ms, Rt |
| Clonality | Pab |
| Format | Lyophilized; PBS; , with 5% trehalose and No Preservative |
| Concentration | 0.2 mg/mL |
| Working Dilution | Immunohistochemistry (Frozen) (5-15 µg/mL), Flow Cytometry (0.25 µg per million cells), Western B... |
| Purity | Antigen affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: PA5-47861 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
