PDI Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA577821 | 100 µL | 666,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, the protein seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. It may therefore cause structural modifications of exofacial proteins. Inside the cell, PDI seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). PDI may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Rat PDI synthetic peptide (409-509 aa C-terminal) conjugated to KLH |
Host | Rb |
Genebank | P4HB |
Isotype | IgG |
Crossreactivity | Bo, Gp, Hm, Hu, Ms, Sh, Pg, Rt, Rhesus Monkey, Xenopus |
Clonality | Pab |
Format | Liquid; PBS; pH 7.4, with 50% glycerol and 0.09% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Western Blot (1:1,000), Immunocytochemistry (1:100), Immunohistochemistry (PFA fixed) (1:1000), I... |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20°C |
Disclaimer | Alternative CatNo: PA5-77821 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |