Pan Ras Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA578035 | 100 µL | 678,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Positive Control: A549, H1299, HCT116, KRAS, HRAS, NRAS, zebrafish liver, zebrafish GI, whole zebrafish Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human KRAS. The exact sequence is proprietary. |
Host | Rb |
Genebank | HRAS |
Isotype | IgG |
Crossreactivity | Amphibian, Hu, Rt, Rodent, Zebrafish |
Clonality | Pab |
Format | Liquid; PBS; pH 7, with 1% BSA, 20% glycerol and 0.025% ProClin 300 |
Concentration | 1 mg/mL |
Working Dilution | Immunocytochemistry (5 µg/mL), Western Blot (1:500-1:10,000), Immunohistochemistry (Paraffin) (1:... |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: PA5-78035 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |