YAP1 Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA578321 | 100 µL | 696,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Positive Control: 293T, A431, HeLa, HepG2 Predicted Reactivity: Mouse (96%), Rat (96%), Zebrafish (87%), Xenopus laevis (81%), Chicken (84%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ChIP, ICC, IHC, IP, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human YAP1. The exact sequence is proprietary. |
| Host | Rb |
| Genebank | YAP1 |
| Isotype | IgG |
| Crossreactivity | Hu |
| Clonality | Pab |
| Format | Liquid; PBS; pH 7, with 1% BSA, 20% glycerol and 0.025% ProClin 300 |
| Concentration | 0.15 mg/mL |
| Working Dilution | Western Blot (1:5,000-1:20,000), Immunoprecipitation (1:100-1:500), Immunohistochemistry (Paraffi... |
| Purity | Antigen affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: PA5-78321 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Wet Ice |
| Material Safety Data Sheet | Download PDF |
