Aggrecan Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA580294 | 100 µL | 395,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human ACAN. Aggrecan also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1 is a protein that is encoded by the ACAN gene. The encoded protein is an integral part of the extracellular matrix in cartilaginous tissue and it withstands compression in cartilage. The human form of the protein is 2316 amino acids long (approximately 250 kDa) and can be expressed in multiple isoforms due to alternative splicing. Aggrecan exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate chains are attached to an extended protein core. The synthesis and degradation of aggrecan are being investigated for their roles in cartilage deterioration during joint injury, disease, and aging. It contains three interglobular domains (IGDs), G1, G2, and G3 that are involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis. Aggrecan fragments from articular cartilage are released into the synovial fluid at all stages of human osteoarthritis as a result of cleavage by aggrecanase and MMP activity. Antibodies BC-3 and BC-4 can be use
Category | Antibody |
Supplier | ThermoFisher |
Application | IHC |
Regulatory Status | RUO |
Immunogen | A synthetic peptide corresponding to the N-terminus of the Human ACAN |
Host | Rb |
Genebank | ACAN |
Isotype | IgG |
Crossreactivity | Hu |
Clonality | Pab |
Format | Liquid; PBS; , with no preservative |
Concentration | 1 mg/mL |
Working Dilution | Immunohistochemistry (Paraffin) (1:500-1:2,000) |
Purity | Protein A/Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C |
Disclaimer | Alternative CatNo: PA5-80294 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |