Tyrosine Hydroxylase Polyclonal Antibody

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Product Description

Keep as concentrated solution. Predicted reactivity: Mouse (92%), Rat (93%), Zebrafish (82%), Japanese Medaka (83%), Xenopus laevis (83%), Dog (96%), Chicken (88%), Bovine (93%). Positive Control: NT2D1, PC-3, U87-MG, SK-N-SH, mouse brain, PC-12, rat brain. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascul