Human Glucocorticoid Receptor (aa 245-259) Synthetic Peptide

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Product Description

PEP-002 is a 15 amino acid (amino acids 245-259) synthetic peptide whose sequence is from the amino terminus of the human glucocorticoid receptor (GR). The sequence of this peptide is (amino to carboxy terminus): C-K-P-L-I-L-P-D-T-K-P-K-I-K-D (The N-terminal cysteine has been added to facilitate conjugation and is not a part of the native human GR sequence) This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the human GR, catalog # PA1-512. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody. Reconstitute with 0.1 mL of distilled water. Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles,