Human Amyloid Precursor Protein Synthetic Peptide
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PEP0048 | 50 µg | 166,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This peptide corresponds to 15 amino acids near the carboxy terminus of human APP. PEP-0048 can be used as a blocking peptide with polyclonal antibody PA5-19923. Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion and axonogenesis. APP is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer's disease. Abnormal regulation and processing of APP also plays a role in Down's syndrome, early onset familial Alzheimer's disease, and cerebral hemorrhage.
Category | Peptide |
Supplier | ThermoFisher |
Application | BL |
Regulatory Status | RUO |
Genebank | APP |
Crossreactivity | Hu |
Format | Liquid; PBS; pH 7.2, with 0.1% BSA and 0.02% sodium azide |
Concentration | 200 µg/mL |
Working Dilution | Blocking Assay (Assay-dependent), Control (Assay-dependent) |
Purity | purified |
Conjugation | Unconjugated |
Storage Conditions | -20°C |
Disclaimer | Alternative CatNo: PEP-0048 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |