Human IL-22 Receptor alpha Synthetic Peptide
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PEP0110 | 50 µg | 167,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This peptide corresponds to 15 amino acids near the carboxy terminus of human IL-22 Receptor. PEP-0110 can be used as a blocking peptide with polyclonal antibody PA5-19986. A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
Category | Peptide |
Supplier | ThermoFisher |
Application | BL |
Regulatory Status | RUO |
Genebank | IL22RA1 |
Crossreactivity | Hu |
Format | Liquid; PBS; pH 7.2, with 0.1% BSA and 0.02% sodium azide |
Concentration | 200 µg/mL |
Working Dilution | Blocking Assay (Assay-dependent), Control (Assay-dependent) |
Purity | purified |
Conjugation | Unconjugated |
Storage Conditions | -20°C |
Disclaimer | Alternative CatNo: PEP-0110 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |