Human TRIM5 alpha (IN2) Synthetic Peptide

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Product Description

This peptide corresponds to 14 amino acids from near the mid-region of human TRIM5 Alpha. PEP-0170 can be used as a blocking peptide with polyclonal antibody PA5-20051. The protein encoded by this gene is a member of the tripartite motif family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coiled-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiquitinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.