Anthrax Lethal Factor Synthetic Peptide
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PEP0211 | 50 µg | 167,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This peptide corresponds to 16 amino acids in the middle of Anthrax lethal factor. Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. LF is the primary toxin of anthrax and functions as a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near their amino terminus, interfering with MAPK signaling and inducing apoptosis.
Category | Peptide |
Supplier | ThermoFisher |
Application | BL |
Regulatory Status | RUO |
Crossreactivity | Bacteria |
Format | Liquid; PBS; pH 7.2, with 0.1% BSA and 0.02% sodium azide |
Concentration | 200 µg/mL |
Working Dilution | Blocking Assay (Assay-dependent), Control (Assay-dependent) |
Purity | purified |
Conjugation | Unconjugated |
Storage Conditions | -20°C |
Disclaimer | Alternative CatNo: PEP-0211 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |