Human PPAR gamma-2 (aa 1-16) Synthetic Peptide

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Product Description

PEP-027 is a 16 amino acid synthetic peptide whose sequence is derived from human PPARg2 and is absent in PPARg1. A COOH-terminal cysteine residue was added for conjugation to KLH. The sequence of this peptide is (amino to carboxy terminus): M (1) G E T L G D S P I D P E S D S (16) C This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and PPARg2, catalog # PA1-824. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody. Reconstitute with 0.1 mL of distilled water. Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed peroxisome proliferator activated receptors (PPARs). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids