Human Myc Tag (aa 410-419) Synthetic Peptide

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Product Description

PEP-035 is an 11 amino acid synthetic peptide whose sequence corresponds to amino acid residues 410-419 of human c-Myc. The sequence of this peptide is (amino to carboxy terminus): (C)-E410-Q-K-L-I-S-E-E-D-L419 (A Cysteine residue was added to the amino terminal to facilitate coupling KLH). This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the cMyc epitope tag, catalog # PA1-981. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody. Reconstitute with 0.1 mL of distilled water. The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Stud