Human CD254 (RANK Ligand) (soluble) Synthetic Peptide
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PEP0421 | 50 µg | 167,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This peptide corresponds to 14 amino acids near the center of human sRANK-L. PEP-0421 can be used as a blocking peptide with polyclonal antibody PA5-20291. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Category | Peptide |
Supplier | ThermoFisher |
Application | BL |
Regulatory Status | RUO |
Genebank | TNFSF11 |
Crossreactivity | Hu |
Format | Liquid; PBS; pH 7.2, with 0.1% BSA and 0.02% sodium azide |
Concentration | 200 µg/mL |
Working Dilution | Blocking Assay (Assay-dependent), Control (Assay-dependent) |
Purity | purified |
Conjugation | Unconjugated |
Storage Conditions | -20°C |
Disclaimer | Alternative CatNo: PEP-0421 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |