Human CD253 (TRAIL) (aa 207-220) Synthetic Peptide

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Product Description

PEP-046 is a 15 amino acid synthetic peptide whose sequence corresponds to residues 207-220 of human TRAIL. The sequence of this peptide is (amino to carboxy terminus): C-V207-Q-Y-I-Y-K-Y-T-S-Y-P-D-P-I220 (The N-terminal cysteine has been added to facilitate conjugation and is not a part of the native human TRAIL sequence) This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and TRAIL, catalog # PA1-955. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Reconstitute with 0.1 mL of distilled water. TRAIL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TRAIL preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR