Human DR5 (aa 255-270) Synthetic Peptide
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PEP048 | 50 µg | 229,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
PEP-048 is a 17 amino acid synthetic peptide whose sequence corresponds to residues 255-270 of human DR5. The sequence of this peptide is (amino to carboxy terminus): C-V255-P-E-Q-E-M-E-V-Q-E-P-A-E-P-T-G270 (The N-terminal cysteine has been added to facilitate conjugation and is not a part of the native human DR5 sequence) This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and DR5, catalog # PA1-957. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Reconstitute with 0.1 mL of distilled water. DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants
Category | Peptide |
Supplier | ThermoFisher |
Regulatory Status | RUO |
Genebank | TNFRSF10B |
Crossreactivity | Hu |
Format | Lyophilized; , with no preservative |
Concentration | 0.5 mg/mL |
Working Dilution | Control (Assay-dependent) |
Purity | purified |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: PEP-048 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |