Human HDAC3 (aa 415-428) Synthetic Peptide

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Product Description

PEP-071 is a 15 amino acid synthetic peptide whose sequence corresponds to residues 415-428 of human HDAC 3 with an amino terminal cysteine added for carrier protein conjugation. The sequence of this peptide is (amino to carboxy terminus): C-D415-G-D-H-D-N-D-K-E-S-P-V-E-I428 This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human HDAC 3, catalog # PA1-862. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Reconstitute with 50 µL of distilled water for a concentration of 1 mg/mL. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thu