Mouse PPAR alpha (aa 8-19) Synthetic Peptide

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Product Description

PEP-181 is a 12 amino acid synthetic peptide whose sequence is derived from mouse PPAR alpha protein with serine 12 being phosphorylated. The sequence of this peptide is (amino to carboxy terminus): Synthetic Peptide: I (8)-C-P-L- (pS)-P-L-E-A-D-D-L (19) This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse phospho-PPAR alpha (Ser12), catalog # PA1-820. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Reconstitute with 0.1 mL of distilled water. Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferator activated receptors (PPAR's). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPAR's are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some