Mouse PDE6B (aa 20-36) Synthetic Peptide

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Product Description

PEP-183 is a 17 amino acid synthetic peptide whose sequence is derived from mouse PDE6 beta protein. The sequence of this peptide is (amino to carboxy terminus): Synthetic Peptide: H (20)-Q-Y-F-G- (K/R)-K-L-S-P-E-N-V-A-G-A-C (36) This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse PDE6 beta, catalog # PA1-722. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Reconstitute with 0.1 mL of distilled water. The second messengers cAMP and cGMP are key regulatory molecules that are involved in a wide variety of signal transduction pathways. Levels of cAMP and cGMP are regulated by their rate of synthesis by nucleotide cyclases and by their rate of hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that catalyze the conversion of 3-prime, 5-prime-cyclic nucleotides to the corresponding nucleoside 5-prime-monophosphates. PDE6 is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. There are five different subunits consisting of rod and cone spe