Mouse S1P1 (aa 359-372) Synthetic Peptide

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Product Description

PEP-220 is a 14 amino acid synthetic peptide corresponding to amino acid residues 359-372 from mouse S1P1. The sequence of this peptide is (amino to carboxy terminus): S (359) H P Q K D D G D N P E T I (372). This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, catalog # PA1-1040. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Reconstitute with 0.1 mL of distilled water. S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. It plays an important role in cell migration via its role in the reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and normal cardiac morphogenesis.