CD31 Monoclonal Antibody (390), Pacific Blue™
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
RM5228 | 1 mL | 442,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | Mouse 32D leukocyte cell line. |
Host | Rt |
Clone Number | [390] |
Genebank | PECAM1 |
Isotype | IgG2a,k |
Crossreactivity | Ms |
Clonality | Mab |
Format | Liquid; PBS; , with 0.1% sodium azide |
Concentration | 0.1 mg/mL |
Working Dilution | Flow Cytometry (Assay-dependent) |
Purity | Affinity chromatography |
Conjugation | Pacific Blue |
Storage Conditions | 4° C |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |