Mouse IL-27 p28 Recombinant Protein
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
RP8611 | 10 µg | 496,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Recombinant mouse p28 is a non-glycosylated protein containing 207 amino acids. Reconstitute using sterile water at 0.1 mg/mL and centrifuge prior to opening vial. Gently pipet solution down the sides of the vial. DO NOT VORTEX sample. Store reconstituted material at -20ºC and add 0.1% BSA for additional stability. IL-27, a member of the IL-12 family, is a heterodimeric protein consisting of the p40-related protein Epstein-Barr virus-induced gene 3 (EBI3) non-covalently linked to an IL-12p35-related protein, p28 (also known as IL-30). IL-27 is produced by activated APCs and mature dendritic cells. IL-27 exerts its activities on NK cells and naive CD4+ T cells; mRNA expression analysis of IL-27 receptor components (WSX-1/TCCR and gp130) suggests that IL-27 may also target other cells, including mast cells and monocytes. Binding of IL-27 to WSX-1/gp130 activates JAK1, STAT1, and STAT3 and STAT1/3 phosphorylation. WSX-1/TCCR-deficient mice develop impaired Th1 responses and are more susceptible to infection with L. monocytogenes suggesting that Th1 responses require IL-27. Although activation of WSX-1 is required for the initiation of Th1 responses, it is not necessary for maintaining Th1 responses. IL-27 alone is not able to induce the differentiation of CD4+ T cel
Category | Protein |
Supplier | ThermoFisher |
Regulatory Status | RUO |
Host | E.coli |
Genebank | IL27 |
Crossreactivity | Ms |
Clonality | Recombi |
Format | Lyophilized; 10mM sodium bicarbonate; pH 8.5, with no preservative |
Concentration | 0.1 mg/mL |
Working Dilution | Control (Assay-dependent) |
Purity | purified |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: RP-8611 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |