MECP2 Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA5143577 | 100 µL | 439,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ICC, IHC, WB |
| Regulatory Status | RUO |
| Immunogen | Full length recombinant human MeCP2 expressed in and purified from E. coli. |
| Host | Ck |
| Genebank | MECP2 |
| Isotype | IgY |
| Crossreactivity | Hu, Ms, Primate, Rt |
| Clonality | Pab |
| Format | Liquid; , with 5mM sodium azide |
| Working Dilution | Western Blot (1:10,000-1:20,000), Immunohistochemistry (PFA fixed) (1:1,000-1:2,000), Immunohisto... |
| Conjugation | Unconjugated |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Disclaimer | Alternative CatNo: PA5-143577 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
