Tyrosine Hydroxylase Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA5143583 | 100 µL | 439,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Full length human TH as expressed in and purified from E. coli. |
Host | Ck |
Genebank | TH |
Isotype | IgY |
Crossreactivity | Hu, Ms, Rt |
Clonality | Pab |
Format | Liquid; , with 5mM sodium azide |
Working Dilution | Flow Cytometry (Assay-dependent), Western Blot (1:50,000), Immunohistochemistry (Paraffin) (1:5,0... |
Conjugation | Unconjugated |
Storage Conditions | 4° C |
Disclaimer | Alternative CatNo: PA5-143583 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |