Aurora B Monoclonal Antibody (3F11)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA547414 | 100 µL | 439,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Aurora-B kinase (AurB) is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumours, including primary breast and colon tumour samples. Its expression in tumours seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Full length recombinant human aurora B protein expressed in and purified from E. coli. |
Host | Ms |
Clone Number | [3F11] |
Genebank | AURKB |
Isotype | IgG2a |
Crossreactivity | Dg, Ho, Hu, Ms |
Clonality | Mab |
Format | Liquid; PBS; , with 50% glycerol and 5mM sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunocytochemistry (1:1,000), Western Blot (1:1,000), Immunohistochemistry (1:1,000) |
Purity | Protein A/G |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA5-47414 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |