EWSR1 Monoclonal Antibody (5H7)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA547453 | 100 µL | 439,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a ttranslocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Full length human EWS expressed in and purified from E. coli. |
Host | Ms |
Clone Number | [5H7] |
Genebank | EWSR1 |
Isotype | IgG2b |
Crossreactivity | Dg, Ho, Hu, Ms, Rt |
Clonality | Mab |
Format | Liquid; PBS; , with 50% glycerol and 5mM sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunocytochemistry (1:1,000), Western Blot (1:1,000-1:2,000), Immunohistochemistry (1:1,000) |
Purity | Protein A/G |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA5-47453 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |